Israel has vowed to respond to Iran’s unprecedented weekend attack, leaving the region bracing for further escalation after months of fighting in Gaza. Israel’s allies have been urging Israel to hold back on any response to the attack that could spiral.

The U.S. on Thursday vetoed a widely backed U.N. resolution that would have paved the way for full United Nations membership for a state of Palestine. The vote in the 15-member Security Council was 12 in favor, the United States opposed and two abstentions.

Separately, the U.S. and Britain announced Thursday that they were imposing a new round of sanctions on Iran. The moves come as EU leaders meeting in Brussels have vowed to ramp up sanctions on Iran to target its drone and missile deliveries to proxies in Gaza, Yemen and Lebanon.

The U.S. sanctions target individuals and entities that produce engines that power drones and are involved in steel production. The latest British measures target several Iranian military organizations, individuals and entities involved in Iran’s drone and ballistic missile industries.